Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA; NIH Center for BioModular Multiscale Systems for Precision Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Biosens Bioelectron. 2019 Apr 1;130:185-203. doi: 10.1016/j.bios.2019.01.037. Epub 2019 Jan 24.
Point-of-care (POC) applications have expanded hugely in recent years and is likely to continue, with an aim to deliver cheap, portable, and reliable devices to meet the demands of healthcare industry. POC devices are designed, prototyped, and assembled using numerous strategies but the key essential features that biosensing devices require are: (1) sensitivity, (2) selectivity, (3) specificity, (4) repeatability, and (5) good limit of detection. Overall the fabrication and commercialization of the nanohole array (NHA) setup to the outside world still remains a challenge. Here, we review the various methods of NHA fabrication, the design criteria, the geometrical features, the effects of surface plasmon resonance (SPR) on sensing as well as current state-of-the-art of existing NHA sensors. This review also provides easy-to-understand examples of NHA-based POC biosensing applications, its current status, challenges, and future prospects.
近年来，即时检测（POC）应用得到了极大的扩展，并且很可能会继续发展，旨在提供廉价、便携和可靠的设备，以满足医疗保健行业的需求。POC 设备使用许多策略进行设计、原型制作和组装，但生物传感设备所需的关键基本特征是：（1）灵敏度，（2）选择性，（3）特异性，（4）可重复性和（5）良好的检测限。总体而言，纳米孔阵列（NHA）设置的制造和商业化仍然是一个挑战。在这里，我们回顾了 NHA 制造的各种方法、设计标准、几何特征、表面等离子体共振（SPR）对传感的影响以及现有 NHA 传感器的最新技术。本综述还提供了基于 NHA 的即时检测生物传感应用的易于理解的示例，包括其当前状态、挑战和未来前景。
