Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710069, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
Sci China Life Sci. 2018 Apr;61(4):400-414. doi: 10.1007/s11427-017-9271-1. Epub 2018 Apr 3.
Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging (MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here.
纳米技术在癌症治疗的生物医学纳米平台的发展中具有广阔的应用前景。磁性纳米粒子结合了磁操作、纳米级发热体、局部磁场和酶模拟等独特的吸引人的特性，推动了基于磁性纳米粒子的癌症药物的开发和应用。在提高磁共振成像（MRI）灵敏度方面取得了相当大的成功，并且应该充分关注磁性纳米粒子的治疗功能。本文综述了基于磁性纳米粒子的癌症治疗的现状和应用。本文强调了磁性纳米粒子的优势，这些优势可能有助于提高临床癌症治疗的疗效。
