Crostelli Marco, Mazza Osvaldo, Mariani Massimo, Mascello Dario, Iorio Carlo
Spine Surgery Unit, Bambino Gesù Pediatric Hospital, Piazza Sant'Onofrio, 4, 00165, Rome, Italy.
Eur Spine J. 2018 Jun;27(Suppl 2):175-181. doi: 10.1007/s00586-018-5597-x. Epub 2018 Apr 19.
Bone substitutes' advantage is enhancing arthrodesis biologic support without further autologous bone graft harvested from other skeleton sites, as from posterior iliac crests; however, in our experience, bone substitutes' integration is often incomplete.
From 2012 to 2017, we operated 108 patients by posterior instrumented vertebral arthrodesis in adolescent idiopathic scoliosis (AIS) correction, mean main curve 80° Cobb, and mean age 12 years and 6 months, with all pedicle screws instrumentation in main curve/curves area and hooks at upper tip of implant; bone graft has been harvested only at vertebral level, without bone substitutes or autologous graft from other patient sites or allogenic bone graft. We matched this group with 98 patients previously operated in which we used calcium triphosphate.
At 3 year mean follow-up, all patients in group treated with autologous bone graft only have complete and stable arthrodesis without loss of correction (mean curve 27° Cobb) or instrumentation failure. At 6 year mean follow-up in the group treated with autologous bone graft augmented by calcium triphosphate, 96 patients have stable arthrodesis without loss of correction (mean curve 24°), 1 case has implant break, and 1 case has 8° Cobb loss of correction.
Bone substitutes are a further cost in arthrodesis surgery and suboptimal integration leaves foreign bodies on vertebras. Our experience shows that all pedicle screw instrumentation and bracing after surgery obtain stable correction showing in time a solid arthrodesis with autologous bone only, harvested at local site, without bone substitutes or further bone graft.
骨替代物的优势在于增强关节融合的生物支持,而无需从其他骨骼部位(如髂后嵴)获取额外的自体骨移植;然而,根据我们的经验,骨替代物的整合往往并不完全。
2012年至2017年,我们对108例青少年特发性脊柱侧凸(AIS)矫正患者进行了后路器械辅助椎体关节融合手术,主弯平均Cobb角为80°,平均年龄为12岁6个月,在主弯区域均使用椎弓根螺钉内固定,并在植入物上端使用钩;仅在椎体水平获取骨移植,未使用骨替代物、来自患者其他部位的自体移植或异体骨移植。我们将该组患者与之前手术的98例使用磷酸三钙的患者进行了匹配。
平均随访3年时,仅接受自体骨移植治疗的组中的所有患者均实现了完全稳定的关节融合,无矫正丢失(平均弯度27° Cobb)或内固定失败。在接受磷酸三钙增强自体骨移植治疗的组中,平均随访6年时,96例患者关节融合稳定且无矫正丢失(平均弯度24°),1例出现植入物断裂,1例出现8° Cobb角的矫正丢失。
骨替代物是关节融合手术中的一项额外费用,且整合欠佳会在椎体上留下异物。我们的经验表明,所有椎弓根螺钉内固定及术后支具固定可获得稳定的矫正效果,及时显示仅使用局部获取的自体骨即可实现坚实的关节融合,无需骨替代物或进一步的骨移植。