First Cardiology Department, Hippokration General Hospital, National and Kapodistrian University of Athens, 115 27, Athens, Greece.
RDM Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Curr Cardiol Rep. 2018 Apr 19;20(6):40. doi: 10.1007/s11886-018-0986-7.
Despite the recent advancements in diagnostic modalities and therapeutic options available, the pathophysiology of pericardial syndromes remains poorly understood. In this review article, we explore the possible links between cardiac adiposity and pericardial syndromes.
Over the last years, the notion of cardiac adipose tissue has radically changed, and its pivotal role in myocardial diseases has been acknowledged. Recent evidence suggests a cross-talk between epicardial fat and the heart. Imaging of epicardial and pericardial adipose tissue has an independent predictive/prognostic value in cardiovascular disease. Recent data suggests that imaging of epicardial adipose tissue may also provide prognostic information on the clinical course of patients with acute pericarditis. Evidence from clinical and translational studies suggests possible links between epicardial fat and pericardial diseases, which need to be further explored. Epicardial adipose tissue could have a role both as a prognostic biomarker in pericardial syndromes and as potential therapeutic target for pericardial diseases. The findings of future research in the field are eagerly anticipated.
尽管目前在诊断方法和治疗选择方面取得了进展，但心包综合征的病理生理学仍未得到很好的理解。在这篇综述文章中，我们探讨了心脏脂肪与心包综合征之间可能存在的联系。
近年来，心脏脂肪组织的概念发生了根本性的变化，其在心肌疾病中的关键作用已得到认可。最近的证据表明心外膜脂肪与心脏之间存在相互作用。心外膜和心包脂肪组织的影像学检查在心脑血管疾病中有独立的预测/预后价值。最近的数据表明，心外膜脂肪组织的影像学检查也可能为急性心包炎患者的临床病程提供预后信息。来自临床和转化研究的证据表明，心外膜脂肪与心包疾病之间可能存在联系，需要进一步探讨。心外膜脂肪组织可能在心包综合征的预后标志物和心包疾病的潜在治疗靶点方面发挥作用。人们热切期待该领域未来研究的结果。
