作为内分泌器官的胃：关键调节基因的表达及其对肥胖和非酒精性脂肪性肝病（NAFLD）的影响
The Stomach as an Endocrine Organ: Expression of Key Modulatory Genes and Their Contribution to Obesity and Non-alcoholic Fatty Liver Disease (NAFLD).
作者信息
Birerdinc Aybike, Stoddard Sasha, Younossi Zobair M
机构信息
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Claude Moore Health Education and Research Building, 3300 Gallows Road, Falls Church, VA, 22042, USA.
Department of Medicine and Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA, USA.
出版信息
Curr Gastroenterol Rep. 2018 Apr 19;20(6):24. doi: 10.1007/s11894-018-0629-6.
PURPOSE OF REVIEW
Obesity is currently seen in epidemic proportions globally and is one of the largest contributors to the development of NAFLD. The spectrum of NAFLD, particularly the progressive forms of NASH, is likely to become the leading cause of liver disease in the next decade.
RECENT FINDINGS
Soluble molecules, encoded by the stomach tissue, have been shown to have pleiotropic effects in both central and peripheral systems involved in energy homeostasis and obesity regulation. As such, the stomach is one of the important players in the complex, multi-system deregulation leading to obesity and NAFLD. The understanding of the stomach tissue as an active endocrine organ that contributes to the signaling milieu leading to the development of obesity and NAFLD is crucial.
综述目的
肥胖目前在全球呈流行趋势，是导致非酒精性脂肪性肝病（NAFLD）的最大因素之一。NAFLD的范围，尤其是非酒精性脂肪性肝炎（NASH）的进展形式，很可能在未来十年成为肝病的主要原因。
最新发现
胃组织编码的可溶性分子已被证明在参与能量平衡和肥胖调节的中枢和外周系统中具有多效性作用。因此，胃是导致肥胖和NAFLD的复杂多系统失调中的重要参与者之一。将胃组织理解为一个有助于形成导致肥胖和NAFLD的信号环境的活跃内分泌器官至关重要。
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