Nan Ze-Dong, Ren Hua-Zhong, Zhao Ming-Bo, Jiang Yong, Tu Peng-Fei
Leshan Vocational & Technical College, Leshan 614000, China.
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(6):1169-1174. doi: 10.19540/j.cnki.cjcmm.2018.0041.
In order to clarify the chemical constituents of Cistanche deserticola cultured in Tarim desert, a systematically phytochemical investigation was carried out. The chemical constituents were isolated by column chromatography, such as silica gel, Sephadex LH-20, MCI gel, ODS and semi-preparative HPLC, and their structures were determined on the basis of MS, NMR spectroscopic analysis, and comparison with literature data. Four compounds were isolated from the 85% ethanol extract of the stems of C. cultured in Tarim desert. Their structures were identified as cis-tubuloside (1), cis-cistanoside (2), cis-cistanoside J (3), and cis-isocistanoside C(4). Compounds 1-4 were four new cis-phenylethanoid glycosides. Herein, we firstly report the ¹H, ¹³C-NMR data of the new compounds(1-4) for the first time. This study will provide the scientific evidence for comprehensively analyzing the chemical constituents of C. deserticola cultured in Tarim desert.
为阐明塔里木沙漠栽培管花肉苁蓉的化学成分，开展了系统的植物化学研究。采用硅胶、葡聚糖凝胶LH - 20、MCI凝胶、ODS柱色谱及半制备高效液相色谱等方法分离化学成分，并通过质谱、核磁共振光谱分析及与文献数据对比确定其结构。从塔里木沙漠栽培管花肉苁蓉茎的85%乙醇提取物中分离得到4个化合物，其结构鉴定为顺式管花苷（1）、顺式肉苁蓉苷（2）、顺式肉苁蓉苷J（3）和顺式异肉苁蓉苷C（4）。化合物1 - 4为4个新的顺式苯乙醇苷类化合物。在此，我们首次报道了新化合物（1 - 4）的¹H、¹³C - NMR数据。本研究将为全面分析塔里木沙漠栽培管花肉苁蓉的化学成分提供科学依据。
