State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
Graduate University of the Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
Org Lett. 2018 May 4;20(9):2702-2706. doi: 10.1021/acs.orglett.8b00913. Epub 2018 Apr 20.
Voacafricines A and B, two unique monoterpenoid indole alkaloids each bearing five fused heterocycles, were obtained from the fruits of Voacanga africana. Their structures were elucidated by extensive spectroscopic methods and computational studies. A plausible biogenetic pathway was proposed from a common precursor, 19- epi-voacristine. Both compounds exhibited potent activity against Staphylococcus aureus and Salmonella typhi, and their activities were superior to those of the well-known antibacterial drugs berberine and fibrauretine.
Voacafricines A 和 B 是从 Voacanga africana 的果实中分离得到的两种具有独特五元并五元杂环的单萜吲哚生物碱。通过波谱数据分析和计算化学研究，确定了它们的结构。并提出了一个可能的生源合成途径，来源于共同的前体 19-表-长春质碱。这两个化合物对金黄色葡萄球菌和伤寒沙门氏菌均有较强的抑制活性，优于常用的抗菌药物小檗碱和蛇根碱。
