Deng Gengguo, Liu Dong
From the Department of Organ Transplantation, Guangdong Second Provincial General Hospital, Guangzhou, China.
Exp Clin Transplant. 2018 Jun;16(3):253-258. doi: 10.6002/ect.2017.0329. Epub 2018 Apr 20.
Organ shortage has long been an obstacle to transplant procedures. As acceptance of aging kidneys from expanded criteria donors increases, the long-term outcomes of renal allografts could be unsatisfactory. The klotho gene, which is known as an antiaging gene that is highly expressed in kidneys, is closely associated with chronic kidney disease and acute kidney injury. Results from existing literature have shown a tendency to support Klotho as a renal protective protein owing to its pleiotropic effects. However, few data are available on Klotho in renal transplant. Whether Klotho serves the same purposes in the renal allograft is still a matter of controversy. This review summarizes new findings from clinical and animal studies reflecting associations between Klotho and renal transplant. A better understanding of the potential effects of Klotho on renal transplant may offer novel insights into ameliorating renal allograft injury.
长期以来，器官短缺一直是移植手术的障碍。随着对扩大标准供体的老龄肾脏的接受度增加，肾移植的长期效果可能并不理想。klotho基因被认为是一种在肾脏中高表达的抗衰老基因，它与慢性肾脏病和急性肾损伤密切相关。现有文献的结果显示，由于其多效性作用，klotho倾向于作为一种肾脏保护蛋白。然而，关于肾移植中klotho的资料很少。klotho在肾移植中是否发挥相同作用仍存在争议。本综述总结了临床和动物研究的新发现，这些发现反映了klotho与肾移植之间的关联。更好地了解klotho对肾移植的潜在影响可能为改善肾移植损伤提供新的见解。
