Laboratory of Molecular Biology, Center for Cancer Research, NCI, Bethesda, MD 20892, USA.
Mol Cell. 2018 Apr 19;70(2):193-194. doi: 10.1016/j.molcel.2018.04.003.
Cold-shocked bacteria transiently shut down protein translation, but the mechanisms whereby they adaptively restore translation were incompletely understood. Zhang et al. (2018) demonstrate a global increase in mRNA structure after cold shock and that, as structured RNA decreases, translation returns, dependent upon ribonuclease RNase R and cold shock protein CspA and its homologs.
冷休克细菌会短暂停止蛋白质翻译，但它们适应地恢复翻译的机制尚不完全清楚。Zhang 等人（2018 年）表明，冷休克后 mRNA 结构会整体增加，并且随着结构 RNA 的减少，翻译恢复，这依赖于核糖核酸酶 RNase R 和冷休克蛋白 CspA 及其同源物。
