Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Cell Commun Signal. 2018 Sep 26;16(1):63. doi: 10.1186/s12964-018-0274-6.
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein-1 (YB-1). Biological activities range from the regulation of transcription, splicing and translation, to the orchestration of exosomal RNA content. Indeed, the secretion of YB-1 from cells via exosomes has opened the door to further potent activities. Evidence links a skewed cold shock protein expression pattern with cancer and inflammatory diseases. In this review the evidence for a causative involvement of cold shock proteins in disease development and progression is summarized. Furthermore, the potential application of cold shock proteins for diagnostics and as targets for therapy is elucidated.
冷休克蛋白是一种多功能的 RNA/DNA 结合蛋白，其特征是存在一个或多个冷休克结构域。在人类中，这个家族中最具特征的成员被称为 Y 盒结合蛋白，如 Y 盒结合蛋白-1（YB-1）。其生物学活性范围从转录、剪接和翻译的调节，到外泌体 RNA 内容的协调。事实上，YB-1 通过外泌体从细胞中分泌出来，为进一步发挥强大的作用开辟了道路。有证据表明，冷休克蛋白表达模式的倾斜与癌症和炎症性疾病有关。本综述总结了冷休克蛋白在疾病发展和进展中因果关系的证据。此外，还阐明了冷休克蛋白在诊断和作为治疗靶点方面的潜在应用。
