The Brain Dynamics Centre, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW 2145, Australia.
Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, CA 94305-5717, USA.
Psychiatry Res. 2018 Jun;264:385-393. doi: 10.1016/j.psychres.2018.03.042. Epub 2018 Mar 19.
Currently there is a very limited understanding of how mental wellbeing versus anxiety and depression symptoms are associated with emotion processing behaviour. For the first time, we examined these associations using a behavioural emotion task of positive and negative facial expressions in 1668 healthy adult twins. Linear mixed model results suggested faster reaction times to happy facial expressions was associated with higher wellbeing scores, and slower reaction times with higher depression and anxiety scores. Multivariate twin modelling identified a significant genetic correlation between depression and anxiety symptoms and reaction time to happy facial expressions, in the absence of any significant correlations with wellbeing. We also found a significant negative phenotypic relationship between depression and anxiety symptoms and accuracy for identifying neutral emotions, although the genetic or environment correlations were not significant in the multivariate model. Overall, the phenotypic relationships between speed of identifying happy facial expressions and wellbeing on the one hand, versus depression and anxiety symptoms on the other, were in opposing directions. Twin modelling revealed a small common genetic correlation between response to happy faces and depression and anxiety symptoms alone, suggesting that wellbeing and depression and anxiety symptoms show largely independent relationships with emotion processing at the behavioral level.
目前，人们对于心理健康与焦虑和抑郁症状之间的关系，特别是它们与情绪处理行为之间的关系，了解非常有限。我们首次使用正性和负性面部表情的行为情绪任务，在 1668 名健康成年双胞胎中研究了这些关联。线性混合模型的结果表明，对快乐面部表情的反应更快与更高的幸福感评分相关，而反应更慢与更高的抑郁和焦虑评分相关。多变量双胞胎模型确定了抑郁和焦虑症状与对快乐面部表情的反应时间之间存在显著的遗传相关性，而与幸福感之间没有任何显著相关性。我们还发现，抑郁和焦虑症状与识别中性情绪的准确性之间存在显著的负表型关系，尽管在多变量模型中，遗传或环境相关性并不显著。总的来说，在识别快乐面部表情的速度与幸福感之间，以及在抑郁和焦虑症状之间，表型关系是相反的。双胞胎模型揭示了快乐面孔反应与抑郁和焦虑症状之间的遗传相关性很小，这表明在行为层面上，幸福感和抑郁、焦虑症状与情绪处理之间存在着很大程度上独立的关系。
