Neuroscience Research Australia, Randwick, New South Wales, Sydney, Australia.
School of Psychology, University of New South Wales, Sydney, NSW, Australia.
BMJ Open. 2022 Jul 1;12(7):e058918. doi: 10.1136/bmjopen-2021-058918.
Mental well-being is a core component of mental health, and resilience is a key process of positive adaptive recovery following adversity. However, we lack an understanding of the neural mechanisms that contribute to individual variation in the trajectories of well-being and resilience relative to risk. Genetic and/or environmental factors may also modulate these mechanisms. The aim of the TWIN-10 Study is to characterise the trajectories of well-being and resilience over 12 years across four timepoints (baseline, 1 year, 10 years, 12 years) in 1669 Australian adult twins of European ancestry (to account for genetic stratification effects). To this end, we integrate data across genetics, environment, psychological self-report, neurocognitive performance and brain function measures of well-being and resilience.
Twins who took part in the baseline TWIN-E Study will be invited back to participate in the TWIN-10 Study, at 10-year and 12-year follow-up timepoints. Participants will complete an online battery of psychological self-reports, computerised behavioural assessments of neurocognitive functions and MRI testing of the brain structure and function during resting and task-evoked scans. These measures will be used as predictors of the risk versus resilience trajectory groups defined by their changing levels of well-being and illness symptoms over time as a function of trauma exposure. Structural equation models will be used to examine the association between the predictors and trajectory groups of resilience and risk over time. Univariate and multivariate twin modelling will be used to determine heritability of the measures, as well as the shared versus unique genetic and environmental contributions.
This study involves human participants. This study was approved by the University of New South Wales Human Research Ethics Committee (HC180403) and the Scientific Management Panel of Neuroscience Research Australia Imaging (CX2019-05). Results will be disseminated through publications and presentations to the public and the academic community. Participants gave informed consent to participate in the study before taking part.
心理健康是心理健康的核心组成部分，韧性是逆境后积极适应恢复的关键过程。然而，我们并不了解有助于幸福感和韧性轨迹相对于风险的个体差异的神经机制。遗传和/或环境因素也可能调节这些机制。TWIN-10 研究的目的是在 1669 名具有欧洲血统的澳大利亚成年双胞胎中，在四个时间点（基线、1 年、10 年和 12 年）上，12 年内描述幸福感和韧性的轨迹（以解释遗传分层效应）。为此，我们整合了遗传学、环境、心理自我报告、神经认知表现和幸福感和韧性的大脑功能测量数据。
参加基线 TWIN-E 研究的双胞胎将被邀请参加 TWIN-10 研究，在 10 年和 12 年的随访时间点。参与者将完成在线心理自我报告、计算机化神经认知功能行为评估以及静息和任务诱发扫描期间的大脑结构和功能的 MRI 测试。这些措施将用作根据创伤暴露，随着时间的推移，幸福感和疾病症状变化水平定义的风险与韧性轨迹组的预测指标。结构方程模型将用于研究随着时间的推移，预测因子与韧性和风险的轨迹组之间的关联。单变量和多变量双胞胎模型将用于确定这些措施的遗传性，以及共享和独特的遗传和环境贡献。
本研究涉及人类参与者。这项研究得到了新南威尔士大学人类研究伦理委员会（HC180403）和澳大利亚神经科学研究成像科学管理小组（CX2019-05）的批准。结果将通过出版物和向公众和学术界的介绍来传播。参与者在参加研究之前已同意参加。
