Tosti A, Manuzzi P, Bardazzi F, Costa A
Department of Dermatology, University of Bologna, Italy.
Dermatologica. 1988;176(3):148-50. doi: 10.1159/000248692.
A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.
