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Is etretinate dangerous in Papillon-Lefèvre syndrome?

作者信息

Tosti A, Manuzzi P, Bardazzi F, Costa A

机构信息

Department of Dermatology, University of Bologna, Italy.

出版信息

Dermatologica. 1988;176(3):148-50. doi: 10.1159/000248692.

Abstract

A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.

摘要

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