Topley J M, Benson J, Squier M V, Chessells J M
Med Pediatr Oncol. 1979;7(4):393-9. doi: 10.1002/mpo.2950070415.
Serial liver function tests and percutaneous liver biopsies were performed on 21 children receiving treatment for acute lymphoblastic leukaemia (ALL). The patients received continuing chemotherapy either with daily 6-mercaptopurine and weekly methotrexate or with five-day pulses of these drugs every three weeks. Liver function tests were transiently abnormal in the majority of children, but the abnormalities bore no relationship to the histology of the liver biopsy. Mild inflammatory and fatty changes were commonly seen, and early portal fibrosis was found in three out of 16 patients biopsied at between 108-130 weeks on treatment. There was no correlation between treatment regime and results of biopsy. Three patients showed possible progression of abnormalities on repeat biopsy. The risk of development of portal fibrosis appears low after 2-3 years of continuing chemotherapy, but examination of liver histology may be indicated if more prolonged therapy is contemplated.
对21名接受急性淋巴细胞白血病（ALL）治疗的儿童进行了系列肝功能检查和经皮肝活检。这些患者持续接受化疗，方案为每日服用6-巯基嘌呤和每周服用甲氨蝶呤，或每三周进行为期五天的这些药物脉冲治疗。大多数儿童的肝功能检查出现短暂异常，但这些异常与肝活检的组织学无关。常见轻度炎症和脂肪变性，在治疗108 - 130周时接受活检的16名患者中，有3名发现早期门脉纤维化。治疗方案与活检结果之间无相关性。3名患者在重复活检时显示异常可能进展。持续化疗2 - 3年后发生门脉纤维化的风险似乎较低，但如果考虑进行更长时间的治疗，可能需要检查肝脏组织学。
