口服甲氨蝶呤在急性淋巴细胞白血病维持治疗中与肌肉注射一样有效。
Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia.
作者信息
Chessells J M, Leiper A D, Tiedemann K, Hardisty R M, Richards S
出版信息
Arch Dis Child. 1987 Feb;62(2):172-6. doi: 10.1136/adc.62.2.172.
Abstract
It has been postulated that variations in methotrexate absorption may influence the outcome of treatment in lymphoblastic leukaemia. One hundred and forty four children with acute lymphoblastic leukaemia not of the T cell type were randomised to receive continuing treatment with daily 6-mercaptopurine, vincristine, and prednisolone six weekly and methotrexate once weekly, either as a single oral dose or an intramuscular injection. Analysis of results with a minimum follow up of three and a half years has shown that the route of administration of methotrexate has had no influence on relapse at any site, but more children receiving intramuscular methotrexate died in remission. These results indicate that oral methotrexate is as effective as intramuscular methotrexate in continuing treatment of lymphoblastic leukaemia.
摘要
据推测，甲氨蝶呤吸收的差异可能会影响淋巴细胞白血病的治疗结果。144名非T细胞型急性淋巴细胞白血病儿童被随机分组，接受持续治疗，即每日服用6-巯基嘌呤、长春新碱，每六周服用一次泼尼松龙，每周服用一次甲氨蝶呤，甲氨蝶呤要么单次口服，要么肌肉注射。对至少随访三年半的结果分析表明，甲氨蝶呤的给药途径对任何部位的复发均无影响，但接受肌肉注射甲氨蝶呤的儿童在缓解期死亡的更多。这些结果表明，在淋巴细胞白血病的持续治疗中，口服甲氨蝶呤与肌肉注射甲氨蝶呤效果相同。
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