急性淋巴细胞白血病维持治疗中并发的肠病
Enteropathy complicating maintenance therapy in acute lymphoblastic leukaemia.
作者信息
Lewis I J, Mainwaring D, Martin J
出版信息
Arch Dis Child. 1982 Sep;57(9):663-7. doi: 10.1136/adc.57.9.663.
Abstract
Seven patients being treated for acute lymphoblastic leukaemia between March 1976 and March 1981, in accordance with Medical Research Council protocols, developed clinical malabsorption while on maintenance chemotherapy. All of them received weekly methotrexate and 6 of the 7 were given co-trimoxazole. Five patients had folate deficiency. Stopping the anti-leukaemic therapy led to a resolution of gastrointestinal symptoms. A combined effect of methotrexate and co-trimoxazole is postulated.
摘要
1976年3月至1981年3月期间，按照医学研究委员会的方案接受急性淋巴细胞白血病治疗的7名患者，在维持化疗期间出现了临床吸收不良。他们所有人都接受每周一次的甲氨蝶呤治疗，7人中有6人还服用了复方新诺明。5名患者存在叶酸缺乏。停止抗白血病治疗后胃肠道症状得到缓解。推测这是甲氨蝶呤和复方新诺明的联合作用。
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