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每日饮用抗氧化等离子体激活水对肺癌的创新治疗策略。

Innovatively Therapeutic Strategy on Lung Cancer by Daily Drinking Antioxidative Plasmon-Induced Activated Water.

机构信息

Department of Animal Science, National Chung Hsing University, No. 250, Guoguang Rd., Taichung, 402, Taiwan.

Division of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University Hospital, No. 252, Wuxing St., Taipei, 11031, Taiwan.

出版信息

Sci Rep. 2018 Apr 20;8(1):6316. doi: 10.1038/s41598-018-24752-x.

DOI:10.1038/s41598-018-24752-x
PMID:29679033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5910416/
Abstract

Many human diseases are inflammation-related, such as cancer and those associated with aging. Previous studies demonstrated that plasmon-induced activated (PIA) water with electron-doping character, created from hot electron transfer via decay of excited Au nanoparticles (NPs) under resonant illumination, owns reduced hydrogen-bonded networks and physchemically antioxidative properties. In this study, it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which further confirms its cellular antioxidative and anti-inflammatory properties. Furthermore, mice implanted with mouse Lewis lung carcinoma (LLC-1) cells drinking PIA water alone or together with cisplatin treatment showed improved survival time compared to mice which consumed only deionized (DI) water. With the combination of PIA water and cisplatin administration, the survival time of LLC-1-implanted mice markedly increased to 8.01 ± 0.77 days compared to 6.38 ± 0.61 days of mice given cisplatin and normal drinking DI water. This survival time of 8.01 ± 0.77 days compared to 4.62 ± 0.71 days of mice just given normal drinking water is statistically significant (p = 0.009). Also, the gross observations and eosin staining results suggested that LLC-1-implanted mice drinking PIA water tended to exhibit less metastasis than mice given only DI water.

摘要

许多人类疾病都与炎症有关，例如癌症和与衰老相关的疾病。先前的研究表明，通过受激 Au 纳米粒子（NPs）激发态衰减产生的具有电子掺杂特性的等离子体诱导激活（PIA）水，其氢键网络减少，并具有物理化学抗氧化特性。在这项研究中，PIA 水显著诱导了人牙龈成纤维细胞中的主要抗氧化 Nrf2 基因，进一步证实了其细胞抗氧化和抗炎特性。此外，与单独饮用 PIA 水或同时饮用 PIA 水和顺铂治疗的植入小鼠 Lewis 肺癌（LLC-1）细胞的小鼠相比，饮用 PIA 水的小鼠的存活时间明显延长。与单独给予顺铂和去离子（DI）水的小鼠相比，给予 PIA 水和顺铂联合治疗的 LLC-1 植入小鼠的存活时间显著增加至 8.01 ± 0.77 天。与仅给予正常饮用水的小鼠 4.62 ± 0.71 天的存活时间相比，8.01 ± 0.77 天的存活时间具有统计学意义（p = 0.009）。此外，大体观察和嗜酸性粒细胞染色结果表明，与仅给予 DI 水的小鼠相比，饮用 PIA 水的 LLC-1 植入小鼠的转移倾向较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/6f7f663ba4b4/41598_2018_24752_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/99bb681f669f/41598_2018_24752_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/24a526767bde/41598_2018_24752_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/021dc29dac7b/41598_2018_24752_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/51cacdc8f6d1/41598_2018_24752_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/f2746e1ff2a3/41598_2018_24752_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/46240cb18de3/41598_2018_24752_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/8944370185d2/41598_2018_24752_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/6f7f663ba4b4/41598_2018_24752_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/99bb681f669f/41598_2018_24752_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/24a526767bde/41598_2018_24752_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/021dc29dac7b/41598_2018_24752_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/51cacdc8f6d1/41598_2018_24752_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/f2746e1ff2a3/41598_2018_24752_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/46240cb18de3/41598_2018_24752_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/8944370185d2/41598_2018_24752_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/888f/5910416/6f7f663ba4b4/41598_2018_24752_Fig8_HTML.jpg

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