Infectious Disease Division, NYU Winthrop Hospital, 222 Station Plaza North (Suite #432), Mineola, NY, 11501, USA.
School of Medicine, State University of New York, Stony Brook, New York, USA.
Eur J Clin Microbiol Infect Dis. 2018 Jul;37(7):1373-1376. doi: 10.1007/s10096-018-3262-2. Epub 2018 Apr 20.
Fever of unknown origin (FUO) refers to fevers of > 101 °F that persist for > 3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. The FUO category determines the focus of the diagnostic workup. In the case presented of an FUO in a young woman, there were clinical findings of both CMV infectious mononucleosis or a lymphoma, e.g., highly elevated ESR, elevated ferritin levels, and elevated ACE level, β-2 microglobulins. The indium scan showed intense splenic uptake. Lymph node biopsy, PET scan, and flow cytometry were negative for lymphoma. CMV infectious mononucleosis was the diagnosis, and she made a slow recovery.
不明原因发热（FUO）是指体温 >101°F 持续 >3 周，且在住院或门诊检查后仍无法明确诊断。FUO 可能由感染性、恶性/肿瘤性、风湿性/炎症性或其他疾病引起。FUO 类别决定了诊断性检查的重点。在该年轻女性 FUO 的病例中，存在巨细胞病毒感染单核细胞增多症或淋巴瘤的临床特征，例如，血沉显著升高、铁蛋白水平升高、血管紧张素转换酶水平升高、β-2 微球蛋白升高。铟扫描显示脾脏摄取增加。淋巴结活检、PET 扫描和流式细胞术均未发现淋巴瘤。巨细胞病毒感染单核细胞增多症的诊断，她的恢复较为缓慢。
