Biotechnology Program, Department of Biology, Indiana University, Bloomington, IN, USA; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA.
Department of Pathology, Microbiology and Immunology, University of South Carolina, Columbia, SC, USA.
Curr Opin Pharmacol. 2018 Aug;41:27-33. doi: 10.1016/j.coph.2018.04.006. Epub 2018 May 22.
The health benefits of soy consumption have long been recognized. An important potential benefit is the linkage of soy consumption with reduced cancer risk. One emerging factor that may confer the anticancer effects of soy is the peptide lunasin. Lunasin has both chemopreventive and therapeutic activities against a variety of carcinogens and cancer types. A novel feature of lunasin is that it contains multiple functional domains that can modulate gene expression through effects on histone acetylation and integrin signaling. Recent studies suggest that lunasin effects on integrin signaling in cancer stem cells reduce expression of stemness factors with a concomitant reduction in metastatic potential. Here, we highlight recent studies of the potential use of lunasin as an anticancer agent and its mode of action.
大豆的食用对健康有益，这一点早已得到认可。其中一个重要的潜在益处是，大豆的食用与降低癌症风险有关。一种新兴的因素可能会赋予大豆的抗癌作用，那就是肽 lunasin。lunasin 具有针对多种致癌物质和癌症类型的化学预防和治疗活性。lunasin 的一个新特点是，它含有多个功能域，通过影响组蛋白乙酰化和整合素信号传导来调节基因表达。最近的研究表明，lunasin 对癌症干细胞中整合素信号的作用会降低干细胞因子的表达，同时降低转移潜力。在这里，我们重点介绍 lunasin 作为抗癌剂的潜在用途及其作用模式的最新研究。
