Department of Chemical Engineering, Pl/La Merced s/n 37008, Universidad de Salamanca, Salamanca, Spain.
Department of Chemical Engineering, Pl/La Merced s/n 37008, Universidad de Salamanca, Salamanca, Spain.
Colloids Surf B Biointerfaces. 2018 Jul 1;167:284-290. doi: 10.1016/j.colsurfb.2018.04.027. Epub 2018 Apr 12.
Polydopamine (PD) is a synthetic melanin pigment of great importance in biomedicine, where its affinity for metallic cations, especially paramagnetic ions, has sparked interest in its use in the development of magnetic resonance imaging (MRI) contrast agents. In this work, we report the cytotoxicity of metal-enriched PD nanoparticles on NIH3T3, a healthy cell line and BT474, a breast cancer cell line. Remarkably, it was found that the metal- enriched PD particles (M = Fe, Fe and Cu) were highly cytotoxic to the breast cancer cells, even after 24 h of treatment. Although, this effect was not selective systems, since an acute cytotoxic effect was also observed on the healthy cell line, this system can be considered as starting point for designing advanced antineoplastic agents.
聚多巴胺（PD）是一种在生物医学中非常重要的合成黑色素颜料，其对金属阳离子的亲和力，尤其是顺磁性离子的亲和力，使其在磁共振成像（MRI）对比剂的开发中引起了关注。在这项工作中，我们报告了金属富集 PD 纳米粒子对 NIH3T3（一种健康细胞系）和 BT474（一种乳腺癌细胞系）的细胞毒性。值得注意的是，研究发现，金属富集 PD 颗粒（M=Fe、Fe 和 Cu）对乳腺癌细胞具有很高的细胞毒性，即使在治疗 24 小时后也是如此。虽然，这种效应不是选择性的，因为在健康细胞系中也观察到了急性细胞毒性效应，但该系统可以被认为是设计先进抗肿瘤药物的起点。
