Aksaray University, Techenical Vocational School, Department of Chemistry Technology, 68100 Aksaray, Turkey.
Aksaray University, Faculty of Science and Letters, Department of Biotechnology and Molecular Biology, 68100 Aksaray, Turkey.
Int J Biol Macromol. 2018 Aug;115:438-446. doi: 10.1016/j.ijbiomac.2018.04.040. Epub 2018 Apr 19.
In the current study, capsaicin, a plant alkaloid with high antioxidative, anti-inflammatory, antiobesity, anticancer and analgesic properties, was used in the film technology for the first time. In the same regard, chitosan (as a versatile animal-based polymer) was blended with capsaicin at three different concentrations to obtain edible films. The produced films were characterized by FT-IR, SEM, and DSC. Mechanical, transmittance, hydrophobicity, anti-quorum sensing, antimicrobial and antioxidant properties were also examined. Incorporation of 0.6 mg of capsaicin into the chitosan matrix (200 mg dissolved in 1% acetic acid solution) was observed as an optimal concentration for boosting up three film properties including mechanical, optical and surface morphology. A continuous improvement was recorded in anti-quorum sensing and antimicrobial activities, antioxidative and hydrophobicity with increasing concentration of capsaicin in the film. In further studies, chitosan-capsaicin blend films can be used as a food packaging material as well dermal and wound healing patches.
在本研究中，辣椒素首次被应用于薄膜技术，这是一种具有高抗氧化、抗炎、抗肥胖、抗癌和镇痛特性的植物生物碱。同样，壳聚糖（一种多用途的动物基聚合物）与辣椒素以三种不同的浓度混合，以获得可食用的薄膜。通过傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和差示扫描量热法（DSC）对所制得的薄膜进行了表征。还对其机械性能、透光率、疏水性、群体感应抑制、抗菌和抗氧化性能进行了研究。将 0.6mg 的辣椒素（溶解在 1%的醋酸溶液中 200mg）加入壳聚糖基质中被观察为最佳浓度，可以提高包括机械性能、光学性能和表面形貌在内的三种薄膜性能。随着薄膜中辣椒素浓度的增加，其群体感应抑制和抗菌活性、抗氧化性和疏水性都得到了持续的改善。在进一步的研究中，壳聚糖-辣椒素共混膜可以用作食品包装材料以及皮肤和伤口愈合贴片。
