Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Curr Opin Immunol. 2018 Aug;53:51-57. doi: 10.1016/j.coi.2018.04.001. Epub 2018 Apr 20.
Influenza viruses are a severe threat to human health and current vaccines do not provide sufficient protection. The highly variable nature of influenza viruses has made the production of efficacious vaccines a challenge. In recent years, a multitude of novel, broadly reactive influenza virus vaccination approaches have been described. What has long seemed impossible could now become reality in the near future-a new generation of influenza virus vaccines that provides long-lasting and broad protection against seasonal as well as potentially pandemic influenza virus strains. This review will discuss new hemagglutinin-based vaccines and their current stage of development.
流感病毒严重威胁人类健康，而现有疫苗并不能提供充分的保护。流感病毒高度易变的特性使得生产有效疫苗成为一项挑战。近年来，出现了多种新型、广泛反应性的流感病毒疫苗接种方法。在不久的将来，长久以来看似不可能的事情现在可能成为现实——新一代流感病毒疫苗能够提供针对季节性和潜在大流行流感病毒株的持久、广泛保护。本文将讨论新型基于血凝素的疫苗及其当前的开发阶段。
