Kiseleva Irina
Department of Virology, Federal State Budgetary ScYientific Institution, Institute of Experimental Medicine, 197376 St Petersburg, Russia.
Faculty of Dental Medicine and Medical Technologies, St Petersburg University, 199034 St Petersburg, Russia.
Vaccines (Basel). 2020 Jul 23;8(3):410. doi: 10.3390/vaccines8030410.
Each year, influenza causes a significant acute respiratory disease burden. In addition, influenza pandemics periodically occur. Annual vaccination is the best tool for influenza prevention, but its effectiveness can vary from year to year. The narrow specificity of conventional vaccines and the drug resistance of currently circulating viruses reduce the effectiveness of prophylaxis and treatment and require the development of new broad-spectrum preparations. Furthermore, the challenge of creating a highly effective universal influenza vaccine takes on renewed intensity in the face of the COVID-19 pandemic.
每年，流感都会造成严重的急性呼吸道疾病负担。此外，流感大流行定期发生。年度疫苗接种是预防流感的最佳工具，但其效果每年可能会有所不同。传统疫苗的特异性狭窄以及当前流行病毒的耐药性降低了预防和治疗的效果，需要开发新的广谱制剂。此外，面对新冠疫情，研发高效通用流感疫苗的挑战再度加剧。
