University of Massachusetts Medical School, Worcester, MA, USA.
King Edward Medical University, Lahore, Pakistan.
Med Oncol. 2018 Apr 21;35(5):77. doi: 10.1007/s12032-018-1138-z.
Pelvic radiation treatment demands precision and consistency in patient setup for efficacy of therapy and to limit radiation dosage to normal tissue. Despite the use of immobilization devices and positioning techniques, there is still concern for variation in daily setup. The purpose of this retrospective study was to determine the presence and degree of variation in sacral slope in 20 subjects receiving radiation therapy for pelvic malignancies.
Each of the 20 subjects received between 20 and 25 fractions of external beam radiation treatment to the pelvis. The sacral slope was measured on each of the daily port films taken prior to treatment and compared to the sacral slope angle measured on the initial treatment planning simulation digitally reconstructed radiographic imaging.
Compared to this initial imaging, the average sacral slope variation across all 20 subjects was 2.27° (± 1.43°), and the average variation among patients ranged from 1.22° to 5.09°. Variation in sacral slope across all 20 subjects from one treatment day to the next was 2.05° (± 1.47°), and ranged from 0.97° to 3.21°.
This study demonstrates that despite the rigorous use of immobilization devices, there still exists day-to-day variation in sacral slope angle between treatment days and compared to initial baseline imaging off which the treatment plan is developed. There is an on-going study at our institution with an attempt to reduce this variation by offering exercises prior to radiation.
盆腔放射治疗需要在患者摆位方面精确且一致,以提高治疗效果并限制正常组织的辐射剂量。尽管使用了固定装置和定位技术,但仍存在对日常摆位变化的担忧。本回顾性研究的目的是确定 20 名接受盆腔恶性肿瘤放射治疗的患者骶骨倾斜度的存在和变化程度。
20 名受试者中的每一位都接受了 20 到 25 次盆腔外照射治疗。在每次治疗前拍摄的每日端口片中测量骶骨斜率,并与初始治疗计划模拟的数字重建放射成像上测量的骶骨斜率角度进行比较。
与初始图像相比,所有 20 名受试者的平均骶骨斜率变化为 2.27°(±1.43°),患者间的平均变化范围为 1.22°至 5.09°。所有 20 名受试者从一天到下一天的骶骨斜率变化为 2.05°(±1.47°),范围为 0.97°至 3.21°。
本研究表明,尽管严格使用固定装置,但在治疗日之间以及与制定治疗计划的初始基线图像相比,骶骨斜率角度仍存在日常变化。我们机构正在进行一项研究,试图通过在放射治疗前提供锻炼来减少这种变化。