Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Department of Gastroenterology and Hematology, Hirosaki National Hospital, Hirosaki, Japan.
Front Immunol. 2018 Apr 6;9:712. doi: 10.3389/fimmu.2018.00712. eCollection 2018.
Suppression of gastric acid by proton pump inhibitors is associated with the increase of in human gut microbiota. Gastric acid secretion is also suppressed by infection and following atrophic gastritis. However, few studies have examined the association between infection and species in gut microbiota particularly in Japan.
A total of 1,123 adult subjects who participated in a health survey in Hirosaki City were studied. Infection of was defined by both serum antibody and stool antigen test. The presence and the severity of atrophic gastritis were defined by the serum level of serum pepsinogens. Using 16S ribosomal RNA amplification from fecal samples, the relative abundance of was calculated, and the composition ratio of each was surveyed.
The relative abundance of the in -infected subjects with severe atrophic gastritis was higher comparing with those in subjects with mild atrophic gastritis and without atrophic gastritis (0.591 vs 0.068% and 0.033%, respectively; < 0.001) and also that of non-infected subjects (0.033%; < 0.001). In non-infected subjects, both gender and age were not associated with the relative abundance of in fecal samples. The proportion of was high in -infected subjects while that of was high in non-infected subjects.
in human gut microbiota could be influenced by infection and severity of atrophic gastritis in Japanese subjects.
质子泵抑制剂抑制胃酸分泌会导致人类肠道菌群中 增加。胃酸分泌也会被 感染和萎缩性胃炎所抑制。然而，很少有研究调查 感染与肠道微生物群中 物种之间的关系，特别是在日本。
共有 1123 名参加弘前市健康调查的成年受试者参与了这项研究。通过血清抗体和粪便抗原检测来定义 的感染。萎缩性胃炎的存在和严重程度通过血清胃蛋白酶原水平来定义。使用粪便样本中的 16S 核糖体 RNA 扩增，计算 的相对丰度，并调查每个 的组成比例。
与轻度萎缩性胃炎和无萎缩性胃炎患者相比，严重萎缩性胃炎患者中 感染的受试者 的相对丰度更高（0.591 对 0.068%和 0.033%；<0.001），也高于未感染的受试者（0.033%；<0.001）。在未感染的非感染者中，性别和年龄与粪便样本中 的相对丰度均无相关性。在 感染的受试者中， 的比例较高，而在未感染的受试者中， 的比例较高。
在日本受试者中， 感染和萎缩性胃炎的严重程度可能会影响肠道微生物群中 的丰度。
