Chen Yi, Ni Bingqian, You Ningning, Chen Yahong, Zhang Jinshun
Departments of Gastroenterology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Departments of Otolaryngology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
Front Cell Infect Microbiol. 2025 May 16;15:1598223. doi: 10.3389/fcimb.2025.1598223. eCollection 2025.
Obesity has become a global health concern, particularly in relation to abdominal fat which is associated with various diseases. The connection between Helicobacter pylori (H. pylori) and obesity is still debated, with limited research on the link between H. pylori and visceral fat. This study aimed to examine the correlation between H. pylori infection and visceral fat area (VFA) among participants.
A total of 18,076 individuals participated in this study, undergoing assessments of VFA, physical parameter measurements, and serum examinations. Bioelectrical impedance was used to analyze VFA, with the triglyceride-glucose (TyG) index indicating levels of insulin resistance (IR) in the population. Multiple linear regression analysis was utilized to determine the factors influencing VFA, while a generalized additive model was employed to assess potential non-linear associations between the TyG index and VFA.
H. pylori was recognized as a contributing factor to VFA exclusively within diabetic populations. In these populations, a significant nonlinear relationship existed between the TyG index and VFA. Furthermore, mediation analysis indicated that the TyG index acted as a mediator in the relationship between H. pylori and VFA.
H. pylori is closely associated with VFA in individuals with diabetes, with IR serving as a mediating factor in the relationship between H. pylori and VFA.
肥胖已成为全球关注的健康问题，尤其是与多种疾病相关的腹部脂肪。幽门螺杆菌（H. pylori）与肥胖之间的联系仍存在争议，关于H. pylori与内脏脂肪之间联系的研究有限。本研究旨在探讨参与者中H. pylori感染与内脏脂肪面积（VFA）之间的相关性。
共有18076人参与本研究，接受了VFA评估、身体参数测量和血清检查。采用生物电阻抗分析法分析VFA，甘油三酯-葡萄糖（TyG）指数表明人群中的胰岛素抵抗（IR）水平。利用多元线性回归分析确定影响VFA的因素，同时采用广义相加模型评估TyG指数与VFA之间潜在的非线性关联。
仅在糖尿病患者群体中，H. pylori被认为是VFA的一个促成因素。在这些群体中，TyG指数与VFA之间存在显著的非线性关系。此外，中介分析表明，TyG指数在H. pylori与VFA的关系中起中介作用。
在糖尿病患者中，H. pylori与VFA密切相关，IR在H. pylori与VFA的关系中起中介作用。
