Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
Department of Dermatology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Int J Dermatol. 2018 Jul;57(7):804-809. doi: 10.1111/ijd.13996. Epub 2018 Apr 16.
Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis.
To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA).
The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704.0 or ICD 10 = L64.9) and 66 patients with actinic keratosis (ICD 9 = 702.0 or ICD 10 = L57.0).
Systemic lupus erythematosus (SLE) was found in 4.37% of all patients with LPP (including CLPP and the FFA subtype) and in 0.31% of controls. Female patients with the FFA subtype were more likely to have SLE than controls (OR 31.034, 95% CI 2.405-400.382, P = 0.0085).
This study is limited in that it is a retrospective chart review.
Female patients with FFA are significantly more likely to have SLE. Patients with LPP (including CLPP and the FFA subtype) are less likely to have diabetes. Patients with CLPP excluding FFA are less likely to have hypertension, heart disease, and hypothyroidism.
扁平苔藓样瘢痕性脱发（LPP）是一种罕见的头皮炎症性淋巴细胞介导的疾病，被认为具有自身免疫发病机制。
确定经典型 LPP（CLPP）和额部纤维性脱发（FFA）患者的合并症患病率。
回顾性分析了 206 例 LPP 患者和 323 例对照患者的病历，以确定现患合并症。对照组由 257 例雄激素性脱发（ICD-9 = 704.0 或 ICD-10 = L64.9）和 66 例光化性角化病（ICD-9 = 702.0 或 ICD-10 = L57.0）患者组成。
所有 LPP 患者（包括 CLPP 和 FFA 亚型）中系统性红斑狼疮（SLE）的患病率为 4.37%，对照组为 0.31%。FFA 亚型的女性患者发生 SLE 的可能性是对照组的 31.034 倍（95%CI 2.405-400.382，P = 0.0085）。
本研究的局限性在于它是一项回顾性图表回顾。
FFA 的女性患者发生 SLE 的可能性明显更高。LPP 患者（包括 CLPP 和 FFA 亚型）发生糖尿病的可能性较低。排除 FFA 的 CLPP 患者发生高血压、心脏病和甲状腺功能减退的可能性较低。
