扁平苔藓样毛发角化病患者的合并症：一项病例对照研究。
Comorbidities in Patients with Lichen Planopilaris: A Case-Control Study.
作者信息
Nasimi Maryam, Garmaroudi Gholamreza, Ghiasi Maryam, Lajevardi Vahideh, Fooladi Zahra, Hassan Zadeh Tabatabaei Mahgol Sadat, Ansari Mahshid Sadat
机构信息
Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Health Education & Promotion, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Skin Appendage Disord. 2022 Jul;8(4):302-306. doi: 10.1159/000522371. Epub 2022 Mar 9.
INTRODUCTION
Lichen planopilaris (LPP) is a lymphocyte-mediated type of scarring alopecia and considered to have autoimmune etiology. Studies about systemic comorbid conditions are limited. Our goal is to identify the prevalence of medical comorbidities in patients with LPP.
METHODS
In a retrospective case-control study, the medical records of 208 LPP patients and 208 controls were reviewed for existing comorbidities such as thyroid diseases, cardiovascular disorders, hypertension, hyperlipidemia, and lupus erythematous.
RESULTS
Hyperlipidemia was found in 41.8% of all patients with LPP and in 17.3% of controls ( value <0.001, OR = 4.167). Chances of hypertension and cardiovascular disorders were lower in the LPP group in comparison to controls ( value = 0.009). Thyroid disorders were more prevalent in LPP patients, but the difference was not statistically significant ( value = 0.277).
CONCLUSION
Our study further emphasizes that LPP patients should be screened for medical comorbidities, especially lipid profile abnormalities.
引言
扁平苔藓性毛发角化病（LPP）是一种淋巴细胞介导的瘢痕性脱发，被认为具有自身免疫病因。关于全身性合并症的研究有限。我们的目标是确定LPP患者中合并症的患病率。
方法
在一项回顾性病例对照研究中，对208例LPP患者和208例对照的病历进行了审查，以了解是否存在甲状腺疾病、心血管疾病、高血压、高脂血症和红斑狼疮等合并症。
结果
在所有LPP患者中，41.8%发现有高脂血症，而对照组为17.3%（ 值<0.001，比值比=4.167）。与对照组相比，LPP组患高血压和心血管疾病的几率较低（ 值=0.009）。甲状腺疾病在LPP患者中更为普遍，但差异无统计学意义（ 值=0.277）。
结论
我们的研究进一步强调，应对LPP患者进行合并症筛查，尤其是脂质谱异常。
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