Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio; George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio.
J Am Acad Dermatol. 2017 Feb;76(2):314-320. doi: 10.1016/j.jaad.2016.05.038.
Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.
The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.
A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Of this cohort, 168 patients met the inclusion criteria.
Androgen excess was identified in 31.5% (n = 53) of the 168 patients with LPP and all subtypes (P < .001). Androgen deficiency was identified in 32.1% (n = 17) of the 53 patients with FFA (P < .001). The androgen excess group was significantly more likely to present with hirsutism, seborrheic dermatitis, polycystic ovary syndrome, ovarian cysts, or a combination of these (P < .001).
This study was limited by being retrospective.
Our study demonstrated that LPP is associated with androgen excess, and FFA is associated with androgen deficiency.
关于扁平苔藓性脱发（LPP）和额部纤维性脱发（FFA）的发病机制和合并症的研究有限。
本研究旨在确定绝经后 LPP 人群中雄激素过多的患病率，以及与人口统计学和合并症的关系。
对 2005 年至 2015 年间在俄亥俄州克利夫兰诊所基金会皮肤科就诊的 413 例 LPP、FFA 和 LPP/FFA 患者进行回顾性数据分析。在该队列中，有 168 例符合纳入标准。
在 168 例 LPP 患者中，有 31.5%（n=53）存在雄激素过多，所有亚型均如此（P<0.001）。在 53 例 FFA 患者中，有 32.1%（n=17）存在雄激素缺乏（P<0.001）。雄激素过多组更有可能出现多毛症、脂溢性皮炎、多囊卵巢综合征、卵巢囊肿或这些情况的组合（P<0.001）。
本研究的局限性在于回顾性。
本研究表明，LPP 与雄激素过多有关，FFA 与雄激素缺乏有关。
