Hosny Salwa S, Bahaaeldin Ahmed M, Khater Mohamed S, Bekhet Meram M, Hebah Hayam A, Hasanin Ghada A
Department of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Geriatric Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Curr Diabetes Rev. 2019;15(3):247-253. doi: 10.2174/1573399814666180423113341.
Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated.
To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI).
Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke's Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP.
Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005).
Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.
2型糖尿病（T2DM）是阿尔茨海默病和轻度认知障碍的危险因素。T2DM患者认知障碍的病因尚不确定，但慢性高血糖、脑微血管疾病、严重低血糖以及大血管疾病患病率增加都与之相关。
测定老年2型糖尿病伴轻度认知障碍（MCI）患者血清可溶性血管黏附分子（sVCAM-1）和高敏C反应蛋白（hs-CRP）水平。
我们对90名老年受试者（年龄60岁及以上）进行了研究。他们被分为三组，第一组30例T2DM伴轻度认知障碍患者，第二组30例无认知障碍的T2DM患者，第三组30名健康受试者作为对照组。对他们进行了病史采集、全面临床检查、人体测量、Addenbrooke认知检查III（ACE---III 2012）、空腹血糖、餐后2小时血糖、糖化血红蛋白、血脂谱、蛋白/肌酐比值、血清sVCAM-1和hs-CRP检测。
MCI的老年糖尿病患者血清sVCAM-1水平（946.7±162.01 ng/ml）显著高于无认知障碍的老年糖尿病患者（479.06±65.27 ng/ml）和对照组（263.7±72.05 ng/ml）（P = 0.002）。MCI的老年糖尿病患者血清Hs-CRP水平显著高于无认知障碍的老年糖尿病患者和对照组（P = 0.005）。
与其他组相比，轻度认知障碍的老年糖尿病患者具有更高水平的可溶性黏附分子和低度全身炎症标志物。
