Wang Yun-Sheng, Ye Jun, Yang Xiao, Zhang Gui-Ping, Cao Yong-Hong, Zhang Rong, Dai Wu, Zhang Qiu
Department of Endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Department of Endocrinology, the Second Hospital of Hefei City, Hefei, Anhui, China.
Arch Med Sci. 2019 Sep;15(5):1203-1216. doi: 10.5114/aoms.2018.79565. Epub 2018 Nov 13.
To investigate the serum retinol binding protein (RBP)-4, cystatin C (Cys C), homocysteine (HCY) and high-sensitivity C-reactive protein (hs-CRP) levels in newly diagnosed type 2 diabetes mellitus (NT2DM) patients, prediabetes mellitus (PDM) subjects and normal controls, as well as their correlation with clinical and laboratory indexes, such as blood pressure and lipoprotein.
A total of 242 subjects, including 141 NT2DM patients, 48 PDM subjects and 53 healthy controls, were recruited in the present study. Serum RBP-4, Cys C and hs-CRP concentrations were measured by enzyme-linked immunosorbent assay (ELISA). HCY concentration was determined by the chemical luminescence method.
There were significant differences in Cys C and hs-CRP among NT2DM patients, PDM subjects and normal controls. In comparison to controls, there were significantly elevated Cys C and hs-CRP levels in PDM (both < 0.001), and a significantly increased Cys C level in NT2DM ( < 0.001); however, there were no significant differences in Cys C and hs-CRP levels between NT2DM and PDM, and no significant differences of hs-CRP levels between NT2DM and normal controls. No significant differences of RBP-4 and HCY levels among NT2DM, PDM and normal control groups were observed.
Aberrant Cys C expression and its clinical associations in NT2DM suggest their important role in this disease.
探讨新诊断2型糖尿病（NT2DM）患者、糖尿病前期（PDM）受试者及正常对照者血清视黄醇结合蛋白（RBP）-4、胱抑素C（Cys C）、同型半胱氨酸（HCY）及高敏C反应蛋白（hs-CRP）水平，以及它们与临床和实验室指标（如血压和脂蛋白）的相关性。
本研究共纳入242名受试者，包括141名NT2DM患者、48名PDM受试者和53名健康对照者。采用酶联免疫吸附测定（ELISA）法检测血清RBP-4、Cys C和hs-CRP浓度。采用化学发光法测定HCY浓度。
NT2DM患者、PDM受试者和正常对照者之间Cys C和hs-CRP存在显著差异。与对照组相比，PDM患者的Cys C和hs-CRP水平显著升高（均P<0.001），NT2DM患者的Cys C水平显著升高（P<0.001）；然而，NT2DM与PDM之间Cys C和hs-CRP水平无显著差异，NT2DM与正常对照之间hs-CRP水平无显著差异。NT2DM、PDM和正常对照组之间RBP-4和HCY水平无显著差异。
NT2DM患者Cys C表达异常及其临床关联提示其在该疾病中起重要作用。
