Department of Chemistry, School of Science , Alzahra University , Vanak, Tehran , Iran.
Chemistry Department, College of Sciences , Shiraz University , Shiraz 71454 , Iran.
Org Lett. 2018 May 4;20(9):2753-2756. doi: 10.1021/acs.orglett.8b00974. Epub 2018 Apr 23.
A novel, and efficient nickel-catalyzed deoxycyanation of phenolic compounds using relatively nontoxic Zn(CN) as the cyanide source was developed. The reaction of C-O bond activated phenolic compounds by 2,4,6-trichloro-1,3,5-triazine with Zn(CN) in the presence of a nickel precatalyst afforded the aromatic nitriles in good to excellent yields.
开发了一种新颖且高效的镍催化酚类化合物脱氰反应，使用相对无毒的 Zn(CN)作为氰源。在镍前催化剂存在下，2,4,6-三氯-1,3,5-三嗪与 Zn(CN)使 C-O 键活化的酚类化合物反应，以良好至优秀的收率得到芳族腈。
