Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Miyata Eye Hospital, Miyazaki, Japan.
PLoS One. 2018 Apr 23;13(4):e0195983. doi: 10.1371/journal.pone.0195983. eCollection 2018.
The purpose of this study is to determine the factors related to anxiety and depression in patients with retinitis pigmentosa (RP). The status of anxiety and depression was determined in RP patients with the Hospital Anxiety and Depression Scale (HADS) questionnaire which consisted of subscales for HADS-anxiety (HADS-A) and HADS-depression (HADS-D). The vision-specific quality of life (VSQOL) was assessed with the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ25). The correlations between the HADS-A or HADS-D scores and vision-related clinical parameters such as the best-corrected visual acuity (BCVA), Functional Acuity Score, Functional Field Score, Functional Vision Score, the NEI- VFQ25 subscale score were determined. The socioeconomic status, such as the work status and membership in the RP society, was investigated to determine the factors related to the HADS-A and HADS-D scores. One hundred and twelve RP patients (46 men and 66 women) with mean age of 60.7±15.4 (standard deviation) years were studied. The HADS-A score was not significantly correlated with any visual functions but was significantly correlated with the general health condition (r = -0.34, P<0.001) and the role limitation (r = -0.20, P = 0.03) of the NEI-VFQ25 subscale. The HADS-D score was significantly correlated with all the visual functions (r = -0.38 to 0.29, P<0.001), the NEI-VFQ25 subscale score (r = - 0.58 to -0.33, P<0.001) by Spearman's correlations. The HADS-A score was significantly higher in the members of the RP society than in non-members (P = 0.013). The mean HADS-D score of employed individuals was significantly lower than that of unemployed ones (P = 0.001) by the Mann-Whitney U test. The results indicate that visual function impairments and vision-related quality of life are associated with a depressive state, and the general health condition is related to anxiety in RP patients. Being employed may be strongly correlated with the degree of depression in RP patients.
本研究旨在确定与色素性视网膜炎（RP）患者焦虑和抑郁相关的因素。采用医院焦虑抑郁量表（HADS）问卷确定 RP 患者的焦虑和抑郁状态，该问卷包括 HADS-焦虑（HADS-A）和 HADS-抑郁（HADS-D）亚量表。采用国家眼科研究所视觉功能问卷 25 项（NEI-VFQ25）评估与视力相关的生活质量。确定 HADS-A 或 HADS-D 评分与视力相关临床参数（最佳矫正视力（BCVA）、功能敏锐度评分、功能视野评分、功能视力评分、NEI-VFQ25 子量表评分）之间的相关性。调查社会经济状况，如工作状况和 RP 协会成员资格，以确定与 HADS-A 和 HADS-D 评分相关的因素。研究了 112 名平均年龄为 60.7±15.4 岁（标准差）的 RP 患者（46 名男性和 66 名女性）。HADS-A 评分与任何视力功能均无显著相关性，但与一般健康状况（r = -0.34，P<0.001）和 NEI-VFQ25 子量表的角色限制（r = -0.20，P = 0.03）显著相关。HADS-D 评分与所有视力功能（r = -0.38 至 0.29，P<0.001）、NEI-VFQ25 子量表评分（r = -0.58 至 -0.33，P<0.001）均显著相关。Spearman 相关分析。RP 协会成员的 HADS-A 评分显著高于非成员（P = 0.013）。Mann-Whitney U 检验显示，就业者的平均 HADS-D 评分显著低于失业者（P = 0.001）。结果表明，视功能障碍和与视力相关的生活质量与抑郁状态相关，一般健康状况与 RP 患者的焦虑相关。就业可能与 RP 患者的抑郁程度密切相关。
