Eissa Yomna K, Ellithy Hend N, Yousry Sherif M, Ismail Zakaria
Clinical Hematology Unit, Internal Medicine Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Clinical Hematology Unit, Internal Medicine Department, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Hematol Oncol Stem Cell Ther. 2018 Dec;11(4):219-224. doi: 10.1016/j.hemonc.2018.03.005. Epub 2018 Apr 17.
The genetic background plays an important role in thrombosis and pregnancy morbidities. Low levels of protein Z is associated with increased risk of thrombosis. The G79A polymorphism in the protein Z gene may be a genetic risk factor for thrombosis.
To investigate the prevalence and clinical significance of the protein Z-79 G/A gene polymorphism in Egyptian patients with antiphospholipid syndrome (APS).
We genotyped 60 APS patients and 41 controls, for protein Z-79 G/A gene polymorphism using the PCR-restriction fragment length. The polymorphism was then analyzed in relation to thrombosis and pregnancy morbidities in APS patients.
We observed a higher prevalence of the A allele in the controls when compared to the APS patients (P Value = <0.001). In our studied sample, the G79A polymorphism, as well as its minor A allele, were not associated with an increased risk of thrombosis or pregnancy morbidities in APS.
Protein Z-79 G/A gene polymorphism may be of a protective value against thrombosis in APS. The G79A polymorphism of protein Z was not found to be an independent risk factor of thrombosis in APS.
遗传背景在血栓形成和妊娠并发症中起重要作用。蛋白Z水平低与血栓形成风险增加有关。蛋白Z基因中的G79A多态性可能是血栓形成的遗传危险因素。
调查埃及抗磷脂综合征（APS）患者中蛋白Z-79 G/A基因多态性的患病率及其临床意义。
我们采用聚合酶链反应-限制性片段长度法对60例APS患者和41例对照者进行蛋白Z-79 G/A基因多态性基因分型。然后分析该多态性与APS患者血栓形成和妊娠并发症的关系。
与APS患者相比，我们观察到对照组中A等位基因的患病率更高（P值＜0.001）。在我们的研究样本中，G79A多态性及其次要A等位基因与APS患者血栓形成或妊娠并发症风险增加无关。
蛋白Z-79 G/A基因多态性可能对APS患者的血栓形成具有保护作用。未发现蛋白Z的G79A多态性是APS患者血栓形成的独立危险因素。
