Sinaiko Alan R, Jacobs David R, Woo Jessica G, Bazzano Lydia, Burns Trudy, Hu Tian, Juonala Markus, Prineas Ronald, Raitakari Olli, Steinberger Julia, Urbina Elaine, Venn Alison, Jaquish Cashell, Dwyer Terry
University of Minnesota Medical School, Department of Pediatrics, 2450 Riverside Avenue, East Building, MB689, Minneapolis, MN 55454, United States.
University of Minnesota School of Public Health, Division of Epidemiology and Community Health, Minneapolis, MN, United States.
Contemp Clin Trials. 2018 Jun;69:55-64. doi: 10.1016/j.cct.2018.04.009. Epub 2018 Apr 22.
Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U.S.) and Australia and a national health database in Finland. Microsoft Access, REsearch Data Capture (REDCap) (U.S.), LimeSurvey (Australia), and Medidata™ Rave data systems are used to collect, transfer and organize data. Self-reported CV events are adjudicated via hospital and doctor-released medical records. After the first two study years, participants (N = 10,968) were more likely to be female (56% vs. 48%), non-Hispanic white (90% vs. 80%), and older (10.4 ± 3.8 years vs. 9.4 ± 3.3 years) at their initial childhood study visit than the currently non-recruited cohort members. Over 48% of cohort members seen during both adulthood and childhood have been found and recruited, to date, vs. 5% of those not seen since childhood. Self-reported prevalences were 0.7% Type 1 Diabetes, 7.5% Type 2 Diabetes, 33% hypertension, and 12.8% CV event. 32% of CV events were judged to be true. I3C Outcomes is uniquely able to establish evidence-based guidelines for child health care and to clarify relations to adult CV disease.
尽管人们普遍认为儿童时期的心血管（CV）危险因素水平与成人心血管疾病有关，但缺乏直接将两者联系起来的纵向数据。本文描述了国际儿童心血管队列联盟结局研究（i3C结局研究）的设计和组织情况，这是第一项纵向队列研究，旨在定位那些拥有详细、重复的儿童期生物学、身体和社会经济测量数据以及统一数据库的成年人。i3C结局研究使用心脏健康调查（HHS）来获取有关成人心血管终点的信息，在美国和澳大利亚通过邮件、电子邮件、电话和门诊就诊的方式进行，在芬兰则利用国家健康数据库。使用微软Access、研究数据采集（REDCap）（美国）、LimeSurvey（澳大利亚）和Medidata™ Rave数据系统来收集、传输和整理数据。自我报告的心血管事件通过医院和医生提供的医疗记录进行判定。在前两个研究年度之后，与目前未招募的队列成员相比，参与者（N = 10968）在其最初的儿童期研究访视时更有可能为女性（56%对48%）、非西班牙裔白人（90%对80%）且年龄更大（10.4±3.8岁对9.4±3.3岁）。迄今为止，在成年期和儿童期均被观察到的队列成员中，超过48%已被找到并招募，而自儿童期以来未被观察到的成员中这一比例为5%。自我报告的患病率为1型糖尿病0.7%、2型糖尿病7.5%、高血压33%以及心血管事件12.8%。32%的心血管事件被判定为真实。i3C结局研究能够独特地为儿童医疗保健建立循证指南，并阐明与成人心血管疾病的关系。
