CRISPR 基因筛选以发现宿主-病毒相互作用。
CRISPR genetic screens to discover host-virus interactions.
机构信息
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA; Gastroenterology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
出版信息
Curr Opin Virol. 2018 Apr;29:87-100. doi: 10.1016/j.coviro.2018.03.007.
Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host-virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host-virus interactions.
病毒给人类健康带来了巨大的负担。为了治疗和预防病毒感染，研究人员进行了基因筛选，以加深对病毒依赖性的理解，并确定潜在的抗病毒策略。CRISPR 基因筛选工具的出现使得这种努力成为可能，因为它使得宿主-病毒筛选能够以比以前更灵活和更忠实的方式进行。在这里，我们回顾了越来越多的 CRISPR 筛选，这些筛选不断加深我们对宿主-病毒相互作用的理解。
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