Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Virol J. 2023 Oct 27;20(1):247. doi: 10.1186/s12985-023-02216-7.
The Flaviviridae virus family members cause severe human diseases and are responsible for considerable mortality and morbidity worldwide. Therefore, researchers have conducted genetic screens to enhance insight into viral dependency and develop potential anti-viral strategies to treat and prevent these infections. The host factors identified by the clustered regularly interspaced short palindromic repeats (CRISPR) system can be potential targets for drug development. Meanwhile, CRISPR technology can be efficiently used to treat viral diseases as it targets both DNA and RNA. This paper discusses the host factors related to the life cycle of viruses of this family that were recently discovered using the CRISPR system. It also explores the role of immune factors and recent advances in gene editing in treating flavivirus-related diseases. The ever-increasing advancements of this technology may promise new therapeutic approaches with unique capabilities, surpassing the traditional methods of drug production and treatment.
黄病毒科病毒成员可引起严重的人类疾病，并在全球范围内导致相当高的死亡率和发病率。因此，研究人员进行了遗传筛选，以深入了解病毒的依赖性，并开发潜在的抗病毒策略来治疗和预防这些感染。CRISPR 系统鉴定的宿主因子可成为药物开发的潜在靶点。同时，CRISPR 技术可有效用于治疗病毒疾病，因为它可靶向 DNA 和 RNA。本文讨论了最近使用 CRISPR 系统发现的与该家族病毒生命周期相关的宿主因子。还探讨了免疫因子的作用以及基因编辑在治疗黄病毒相关疾病方面的最新进展。该技术的不断进步可能预示着具有独特功能的新型治疗方法，超越了传统的药物生产和治疗方法。
