脂联素 45T/G 多态性与韩国 2 型糖尿病患者心血管并发症的关系。
Association of Adiponectin 45T/G Polymorphism with Diabetic Cardiovascular Complications in Korean Type 2 Diabetes.
机构信息
Department of Internal Medicine, SynWoo Hospital, Seongnam, Korea.
Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
出版信息
J Korean Med Sci. 2018 Apr 3;33(17):e124. doi: 10.3346/jkms.2018.33.e124. eCollection 2018 Apr 23.
BACKGROUND
Adiponectin is an adipokine that regulates lipid and glucose metabolism and has been shown to have anti-inflammatory and anti-atherogenic effects. It also plays an important role in the development of cardiovascular disease (CVD).
METHODS
This study evaluated the association between adiponectin 45T/G polymorphism and cardiovascular complication in type 2 diabetes in Koreans.
RESULTS
The present study included 758 patients with type 2 diabetes. The distribution of the adiponectin 45T/G polymorphism was 3.56% (n = 27) for GG, 42.35% (n = 321) for TG, and 54.09% (n = 410) for TT in patients with type 2 diabetes. The prevalence of CVD was significantly higher in subjects with the GG + TG genotype compared to those with the TT genotype (17.5% vs. 9.8%, = 0.002). The G allele was associated with a higher risk of CVD ( = 0.002).
CONCLUSION
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
背景
脂联素是一种调节脂质和葡萄糖代谢的脂肪因子，具有抗炎和抗动脉粥样硬化作用。它在心血管疾病（CVD）的发展中也起着重要作用。
方法
本研究评估了韩国 2 型糖尿病患者脂联素 45T/G 多态性与心血管并发症的关系。
结果
本研究共纳入 758 例 2 型糖尿病患者。脂联素 45T/G 多态性在 2 型糖尿病患者中的分布为 GG 基因型占 3.56%（n=27），TG 基因型占 42.35%（n=321），TT 基因型占 54.09%（n=410）。与 TT 基因型相比，GG+TG 基因型患者 CVD 的患病率明显更高（17.5% vs. 9.8%， = 0.002）。G 等位基因与 CVD 的风险增加相关（ = 0.002）。
结论
我们的研究结果表明，脂联素 45T/G 多态性与 2 型糖尿病的糖尿病心血管并发症有关。
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