中国四川省汉族人群脂联素基因（ADIPOQ）+45 T>G多态性与代谢综合征的关联
Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China.
作者信息
Li Xiaotong, Wei Daying, He Huijing, Zhang Jianhua, Wang Chunxiu, Ma Mingju, Wang Bin, Yu Tao, Pan Li, Xue Fang, He Haiqing, Xu Weiwei, Pan Tingfang, Zuo Qian, Ulf Lindblad, Shan Guangliang
机构信息
Department of Epidemiology and Health Statistics, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
出版信息
Asia Pac J Clin Nutr. 2012;21(2):296-301.
The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T>G polymorphism and the metabolic syndrome was independent of multiple confounders.
代谢综合征是一组以肥胖、糖代谢受损、高血压或血压升高以及血脂异常为特征的异常情况。本研究的目的是调查脂联素基因（ADIPOQ）+45 T>G多态性与中国四川省汉族人群代谢综合征之间的关联。采用病例对照设计，纳入116例代谢综合征患者和108例年龄及性别相匹配的无关对照。与TT基因型受试者相比，在调整了教育程度、体力活动、相关疾病家族史、吸烟和饮酒因素后，ADIPOQ +45G等位基因（TG+GG）与代谢综合征风险存在显著关联（比值比=1.88，95%置信区间：1.03 - 3.44，p=0.039）。ADIPOQ +45 T>G多态性与代谢综合征之间的关联独立于多个混杂因素。
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