Mello Fernanda Weber, Melo Gilberto, Meurer Maria Inês, Rivero Elena Riet Correa
Postgraduate Program in Dentistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Department of Pathology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
J Oncol. 2018 Mar 1;2018:2325808. doi: 10.1155/2018/2325808. eCollection 2018.
The aim of this study was to investigate the characteristics of individuals with intraoral potentially malignant disorders (IOPMD) in an oral pathology service in Brazil. Cases were screened based on clinical diagnosis of leukoplakia (LKP), erythroleukoplakia (ELKP), and erythroplakia (EP). Clinical data and information regarding associated factors were gathered from biopsy reports. Histological diagnoses were collected from histopathological records. Among 208 IOPMD cases, 84.13% involved LKP; 11.1%, ELKP; and 4.8%, EP. The most affected sites were the gingiva and buccal mucosa. Histologically, epithelial dysplasia was present in 66.8% of the lesions, acanthosis and hyperkeratosis without epithelial dysplasia were present in 27.9%, and squamous cell carcinoma was present in 2.9%. Most patients were males, fair-skinned, with mean age of 53.4 years. Chronic smokers represented 73% of subjects, of which 30% also consumed alcohol. Smokers and drinkers were mostly males ( < 0.001). EP and ELKP represented histologically more severe degrees of epithelial dysplasia than LKP ( < 0.001). In conclusion, individuals with IOPMD were more frequently fair-skinned men in the sixth decade of life, with smoking habit. Special attention is required to clinical diagnoses of ELKP and EP since the prevalence of severe epithelial dysplasia, in situ carcinoma, and squamous cell carcinoma is higher than in LKP.
本研究旨在调查巴西一家口腔病理科中患有口腔潜在恶性疾病（IOPMD）的个体特征。根据白斑（LKP）、红白斑（ELKP）和红斑（EP）的临床诊断对病例进行筛查。从活检报告中收集临床数据及相关因素的信息。从组织病理学记录中收集组织学诊断结果。在208例IOPMD病例中，84.13%为LKP；11.1%为ELKP；4.8%为EP。最常受累的部位是牙龈和颊黏膜。组织学上，66.8%的病变存在上皮发育异常，27.9%存在无上皮发育异常的棘层增厚和角化过度，2.9%存在鳞状细胞癌。大多数患者为男性，皮肤白皙，平均年龄53.4岁。慢性吸烟者占受试者的73%，其中30%也饮酒。吸烟者和饮酒者大多为男性（P<0.001）。与LKP相比，EP和ELKP在组织学上代表上皮发育异常的更严重程度（P<0.001）。总之，患有IOPMD的个体更常见于60岁左右有吸烟习惯的皮肤白皙男性。由于ELKP和EP中重度上皮发育异常、原位癌和鳞状细胞癌的患病率高于LKP，因此需要对其临床诊断给予特别关注。
