Olsen Ingar, Chen Tsute, Tribble Gena D
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Department of Microbiology, Forsyth Institute, Cambridge, MA, USA.
J Oral Microbiol. 2018 Apr 12;10(1):1457373. doi: 10.1080/20002297.2018.1457373. eCollection 2018.
is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of . The present review discusses how the exchange of alleles can convert this bacterium from commensalistic to pathogenic and potentially shapes the host-microbe environment from homeostasis to dysbiosis. It is likely that genotypes of with increased pathogenic adaptations may spread in the human population with features acquired from a common pool of alleles. The exact molecular mechanisms that trigger this exchange are so far unknown but they may be elicited by environmental pressure.
被认为是成人牙周炎的关键病原体，但也与全身性疾病有关。它有无数种毒力因子，不同菌株之间存在差异。基因交换和细胞内基因组重排可能是其毒力变异的原因。本综述讨论了等位基因的交换如何使这种细菌从共生状态转变为致病状态，并可能将宿主-微生物环境从稳态转变为失调状态。具有增强致病适应性的基因型可能会在人群中传播，并带有从共同等位基因库中获得的特征。迄今为止，触发这种交换的确切分子机制尚不清楚，但可能是由环境压力引发的。
