Zhou Jun, Cheng Zhi Ming
Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, 215000, Suzhou, China.
Appl Biochem Biotechnol. 2024 Dec;196(12):8809-8819. doi: 10.1007/s12010-024-04928-0. Epub 2024 Jul 2.
The purpose of this investigation was to evaluate the efficacy of ultrasonic subgingival curettage in conjunction with antibacterial polypeptide periodontal gel in the management of chronic periodontitis of moderate to severe severity. Methods included dividing 500 hospitalised patients with moderate to severe chronic periodontitis evenly between an observation group and a control group. Subgingival ultrasonic curettage was performed on the placebo group. The non-treatment group received ultrasonic subgingival curettage and a periodontal gel rinse containing polypeptides. Results were compared before and after treatment in terms of the periodontal index, inflammation in the gingival crevicular fluid, and occlusal and masticatory efficiency. Both groups saw significant reductions in occlusal duration and occlusal force balance after treatment compared to pre-treatment levels, though the observation group saw a more dramatic decrease in these indices than the control group with P ≤ 0.05. The treatment and observation groups both saw significant reductions in the masticatory efficiency standard deviation afterward, but the index in the observation group was significantly lower than that of the control group with P ≤ 0.05.The authors claim that moderate to severe chronic periodontitis can be effectively treated with a combination of polypeptide periodontal gel and ultrasonic subgingival curettage. Substantial decreases from pre-treatment levels for both groups, with the Observation Group's index being significantly lower than the Control Group's index (P ≤ 0.05). It is possible that this treatment will help reduce inflammation and improve your periodontal health. Biting strength and occlusion stability can both be improved at the same time to help patients improve their chewing efficiency. Therefore, this method can be used securely in real-world patient care settings.
本研究的目的是评估超声龈下刮治联合抗菌多肽牙周凝胶治疗中重度慢性牙周炎的疗效。方法包括将500例中重度慢性牙周炎住院患者平均分为观察组和对照组。安慰剂组进行龈下超声刮治。非治疗组接受龈下超声刮治和含多肽的牙周凝胶冲洗。比较治疗前后两组的牙周指数、龈沟液炎症、咬合及咀嚼效率。与治疗前相比,两组治疗后咬合持续时间和咬合力平衡均显著降低,但观察组这些指标的下降幅度比对照组更显著,P≤0.05。治疗组和观察组咀嚼效率标准差治疗后均显著降低,但观察组该指标显著低于对照组,P≤0.05。作者称,多肽牙周凝胶联合超声龈下刮治可有效治疗中重度慢性牙周炎。两组治疗后较治疗前均有显著下降,观察组指标显著低于对照组(P≤0.05)。这种治疗方法可能有助于减轻炎症,改善牙周健康。同时可提高咬合力和咬合稳定性,帮助患者提高咀嚼效率。因此,该方法可安全用于实际患者护理中。