Olsen Ingar, Singhrao Sim K, Osmundsen Harald
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Dementia & Neurodegeneration Research Group, Faculty of Clinical and Biomedical Sciences, School of Dentistry, University of Central Lancashire, Preston, UK.
J Oral Microbiol. 2017 Jun 12;9(1):1333396. doi: 10.1080/20002297.2017.1333396. eCollection 2017.
is considered a keystone pathogen in periodontitis, a disease typically driven by dysbiosis of oral inflammophilic polymicrobial pathobionts. To combat infectious agents, the natural defense response of the host is to switch on inflammatory signaling cascades, whereby microRNA (miRNA) species serve as alternative genetic inhibitory transcriptional endpoints. miRNA profiles from diseased sites differ from those detected in disease-free tissues. miRNA profiles could therefore be harnessed as potential diagnostic/prognostic tools. The regulatory role of some miRNA species (miRNA-128, miRNA-146, miRNA-203, and miRNA-584) in the innate immune system suggests these molecular signatures also have potential in therapy. -associated miRNAs are likely to influence the innate immune response, whereas its lipopolysaccharide may affect the nature of host miRNAs and their mRNA targets. This mini review discusses miRNA-dependent transcriptional and regulatory phenomena ensuing immune signaling cascade switch-on with development and progression of periodontitis initiated by exposure.
被认为是牙周炎中的关键病原体，牙周炎是一种通常由口腔嗜炎多微生物致病共生菌的生态失调驱动的疾病。为了对抗感染因子，宿主的自然防御反应是开启炎症信号级联反应，由此微小RNA（miRNA）作为替代性遗传抑制转录终点发挥作用。患病部位的miRNA谱与在无病组织中检测到的不同。因此，miRNA谱可作为潜在的诊断/预后工具。一些miRNA（miRNA-128、miRNA-146、miRNA-203和miRNA-584）在先天免疫系统中的调节作用表明这些分子特征在治疗中也具有潜力。与 相关的miRNA可能会影响先天免疫反应，而其脂多糖可能会影响宿主miRNA及其mRNA靶标的性质。这篇综述讨论了由暴露引发的牙周炎的发展和进展过程中，miRNA依赖的转录和调节现象引发免疫信号级联反应的开启。
