Ely Brett R, Clayton Zachary S, McCurdy Carrie E, Pfeiffer Joshua, Minson Christopher T
Department of Human Physiology, University of Oregon, Eugene, OR, USA.
Peace Health Medical Group, Oregon Bariatric Center, Springfield, OR, USA.
Temperature (Austin). 2017 Nov 10;5(1):9-21. doi: 10.1080/23328940.2017.1384089. eCollection 2018.
Obesity and associated metabolic dysfunction have reached epidemic proportions worldwide. The current theory linking metabolic disease and obesity involves ischemic adipose tissue initiating an inflammatory cascade that results in systemic insulin resistance and may eventually lead to type II diabetes mellitus. Diabetes and associated metabolic dysfunction increase the risk of developing cardiovascular disease and fatal cardiovascular events. By targeting key steps in this process, ischemia and inflammation, this cascade may be prevented or reversed and thus metabolic and cardiovascular health may be preserved in obesity. Regular heat exposure (termed 'heat therapy') offers potential to improve cardiometabolic health in obese individuals through a variety of mechanisms that include but are not limited to heat shock proteins, hypoxia-inducible factor 1α, and hemodynamic effects. The purpose of this review is to highlight the cardiometabolic decline in obese individuals stemming from adipose tissue dysfunction, and examine the ways in which heat therapy and associated cellular and systemic adaptations can intersect with this decline in function to improve or restore cardiovascular and metabolic health.
肥胖及相关代谢功能障碍在全球范围内已达到流行程度。目前将代谢性疾病与肥胖联系起来的理论认为，缺血性脂肪组织引发炎症级联反应，导致全身胰岛素抵抗，并最终可能引发II型糖尿病。糖尿病及相关代谢功能障碍会增加患心血管疾病和致命心血管事件的风险。通过针对这一过程中的关键步骤，即缺血和炎症，这种级联反应可能被预防或逆转，从而在肥胖人群中维持代谢和心血管健康。定期热暴露（称为“热疗法”）有可能通过多种机制改善肥胖个体的心脏代谢健康，这些机制包括但不限于热休克蛋白、缺氧诱导因子1α和血流动力学效应。本综述的目的是强调肥胖个体因脂肪组织功能障碍导致的心脏代谢功能衰退，并探讨热疗法及相关细胞和全身适应性变化如何与这种功能衰退相互作用，以改善或恢复心血管和代谢健康。
