Defagó Maria Daniela, Eynard Aldo Renato
Escuela de Nutrición. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba.
Instituto de Investigaciones en Ciencias de la Salud (INICSA), CONICET, Córdoba, Argentina..
Rev Fac Cien Med Univ Nac Cordoba. 2022 Jun 6;79(2):168-180. doi: 10.31053/1853.0605.v79.n2.30289.
From nutrigenetics, the genetic variation to dietary response, it is possible to understand and modulate the clinical response conditioned by the genotype by the diet.
to explore the bibliographic evidence on the potential of nutrigenetics in the approach and treatment of cardiovascular diseases (CVD) and associated risk factors.
a systematic search was carried out in the electronic databases MEDLINE, EMBASE and Google Scholar. Those articles that contained the keywords or a combination of them, during 1990-2019, from both experimental and observational studies, were included.
49 articles were included, classified according to the main molecular pathways involved in the etiopathogenesis of CVD. Although a wide diversity of genetic variants was found that confer susceptibility to CVD and risk factors such as obesity, dyslipidemia and arterial hypertension, there is little consistency in the publication of replication studies.
the knowledge of genetic variants allows the personalization of the diet, which can be complemented with other healthy recommendations associated with the lifestyle. More studies in large populations and meta-analyzes are necessary to unequivocally show the gene-nutrient relationship.
从营养遗传学，即基因变异对饮食反应的影响来看，通过饮食了解并调节由基因型决定的临床反应是可行的。
探讨营养遗传学在心血管疾病（CVD）及其相关危险因素的处理和治疗中的潜在作用的文献证据。
在电子数据库MEDLINE、EMBASE和谷歌学术上进行了系统检索。纳入了1990年至2019年期间来自实验性和观察性研究、包含关键词或其组合的文章。
纳入了49篇文章，根据CVD发病机制中涉及的主要分子途径进行分类。尽管发现了多种导致CVD易感性以及肥胖、血脂异常和动脉高血压等危险因素的基因变异，但复制研究的发表结果几乎没有一致性。
了解基因变异有助于饮食的个性化，这可以与其他与生活方式相关的健康建议相辅相成。需要在大量人群中进行更多研究和荟萃分析，以明确显示基因与营养素之间的关系。
