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瑞典髋部骨折患者的生理与手术严重程度评分用于死亡率和发病率计数的准确性以及诺丁汉风险评分——一项前瞻性观察研究。

Accuracy of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity score and the Nottingham risk score in hip fracture patients in Sweden - A prospective observational study.

作者信息

Jonsson M H, Bentzer P, Turkiewicz A, Hommel A

机构信息

Department of Anaesthesia and Intensive Care Medicine, Ystad Hospital, Ystad, Sweden.

Department of Clinical Sciences, Lund University, Lund, Sweden.

出版信息

Acta Anaesthesiol Scand. 2018 Sep;62(8):1057-1063. doi: 10.1111/aas.13131. Epub 2018 Apr 23.

Abstract

BACKGROUND

Little is known about accuracy of common risk prediction scores in elderly patients suffering from hip fractures. The objective of this study was to investigate accuracy of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) score, Portsmouth-POSSUM (P-POSSUM) score and the Nottingham Hip Fracture Score (NHFS) for prediction of mortality and morbidity in this patient group.

METHODS

This was a prospective single centre observational study on 997 patients suffering out-of-hospital cervical, trochanteric or subtrochanteric fracture of the neck of the femur. Calibration and discrimination was assessed by calculating the ratio of observed to expected events (O:E) and areas under receiver operating characteristics curves (ROC).

RESULTS

The 30-day mortality was 6.2% and complications, as defined by POSSUM, occurred in 41% of the patients. Overall O:E ratios for POSSUM, P-POSSUM and NHFS scores for 30-day mortality were 0.90, 0.98, and 0.79 respectively. The models underestimated mortality in the lower risk bands and overestimated mortality in the higher risk bands. In contrast, POSSUM predicted morbidity well with O:E ratios close to unity in most risk bands. The areas under the ROC curves for the scoring systems was 0.60-0.67.

CONCLUSION

The POSSUM score and NHFS show moderate calibration and poor discrimination in this cohort. The results suggest that mortality and morbidity in hip fracture patients are largely dependent on factors that are not included in these scores.

摘要

背景

对于髋部骨折老年患者中常见风险预测评分的准确性知之甚少。本研究的目的是调查生理与手术严重程度评分系统(POSSUM)、朴茨茅斯 - POSSUM(P - POSSUM)评分以及诺丁汉髋部骨折评分(NHFS)在预测该患者群体死亡率和发病率方面的准确性。

方法

这是一项针对997例院外股骨颈颈椎、转子间或转子下骨折患者的前瞻性单中心观察性研究。通过计算观察到的与预期事件的比率(O:E)以及受试者工作特征曲线(ROC)下的面积来评估校准和辨别能力。

结果

30天死亡率为6.2%,按照POSSUM定义的并发症发生在41%的患者中。POSSUM、P - POSSUM和NHFS评分的30天死亡率总体O:E比率分别为0.90、0.98和0.79。这些模型在低风险组低估了死亡率,在高风险组高估了死亡率。相比之下,POSSUM在大多数风险组中对发病率的预测较好,O:E比率接近1。评分系统的ROC曲线下面积为0.60 - 0.67。

结论

在该队列中,POSSUM评分和NHFS显示出中等校准和较差的辨别能力。结果表明,髋部骨折患者的死亡率和发病率在很大程度上取决于这些评分未包含的因素。

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