元桥接技术：通过代谢物的直接蛋白质互作体实现基于网络的综合分析。
MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites.
机构信息
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada.
出版信息
Bioinformatics. 2018 Sep 15;34(18):3225-3227. doi: 10.1093/bioinformatics/bty331.
SUMMARY
Here, we present MetaBridge, a tool that collates protein interactors (curated metabolite-enzyme interactions) that influence the levels of specific metabolites including both biosynthetic and degradative enzymes. This enables network-based integrative analysis of metabolomics data with other omics data types. MetaBridge is designed to complement a systems-biology approach to analysis, pairing well with network analysis tools such as NetworkAnalyst.ca, but can be used in any bioinformatics workflow.
AVAILABILITY AND IMPLEMENTATION
MetaBridge has been implemented as a web tool at https://www.metabridge.org, and the source code is available at https://github.com/samhinshaw/metabridge_shiny (GNU GPLv3).
摘要
在这里，我们展示了 MetaBridge，这是一个工具，可以整理影响特定代谢物水平的蛋白质相互作用物（经过精心策划的代谢物-酶相互作用），包括生物合成和降解酶。这使得能够对代谢组学数据与其他组学数据类型进行基于网络的综合分析。MetaBridge 的设计旨在补充系统生物学分析方法，与 NetworkAnalyst.ca 等网络分析工具配合得很好，但也可以在任何生物信息学工作流程中使用。
可用性和实现
MetaBridge 已作为一个网络工具在 https://www.metabridge.org 上实现，其源代码可在 https://github.com/samhinshaw/metabridge_shiny（GNU GPLv3）上获得。
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