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气管内接种溶血巴斯德氏菌细胞毒素对大鼠肺完整性的影响。

Effect of intratracheal inoculation of Pasteurella haemolytica cytotoxin on the integrity of rat lung.

作者信息

Lopez A, Yong S, Shewen P

机构信息

Animal Sciences Wing, Alberta Environmental Centre, Vegreville.

出版信息

Can J Vet Res. 1987 Oct;51(4):533-5.

PMID:2968834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1255381/
Abstract

This study was conducted to investigate the in vivo effect of a single intratracheal inoculation of Pasteurella haemolytica cytotoxin on the rat lung. Changes in the biochemical and cytological composition of bronchoalveolar lavage fluid were used to estimate the magnitude of pulmonary cell injury, inflammatory response, vascular permeability and functional status of pulmonary alveolar macrophages. Effect of treatment was compared with rats intratracheally inoculated with supernatants of Pasteurella multocida or with sterile physiological saline solution (vehicle). Results indicated that Pasteurella haemolytica supernatants were not significantly toxic for the lungs of rats.

摘要

本研究旨在探讨经气管内单次接种溶血巴斯德氏菌细胞毒素对大鼠肺部的体内作用。利用支气管肺泡灌洗液体生化和细胞学组成的变化来评估肺细胞损伤程度、炎症反应、血管通透性及肺泡巨噬细胞的功能状态。将治疗效果与经气管内接种多杀巴斯德氏菌上清液或无菌生理盐溶液（赋形剂）的大鼠进行比较。结果表明，溶血巴斯德氏菌上清液对大鼠肺部无明显毒性。

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本文引用的文献

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Evidence of species specificity in the cytocidal effects of Pasteurella haemolytica.溶血巴斯德氏菌细胞杀伤作用中物种特异性的证据。
Infect Immun. 1980 Nov;30(2):615-6. doi: 10.1128/iai.30.2.615-616.1980.
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Early damage indicators in the lung. V. Biochemical and cytological response to NO2 inhalation.肺早期损伤指标。V. 吸入二氧化氮后的生化和细胞学反应。
Toxicol Appl Pharmacol. 1981 Sep 15;60(2):301-12. doi: 10.1016/0041-008x(91)90233-5.
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Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes.溶血巴斯德氏菌作用于牛白细胞的细胞毒素。
Infect Immun. 1982 Jan;35(1):91-4. doi: 10.1128/iai.35.1.91-94.1982.
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Metabolic activation and lung toxicity: a basis for cell-selective pulmonary damage by foreign chemicals.代谢活化与肺毒性：外源化学物质导致细胞选择性肺损伤的基础。
Environ Health Perspect. 1984 Apr;55:47-51. doi: 10.1289/ehp.845547.
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The role of toxicological interactions in lung injury.毒理学相互作用在肺损伤中的作用。
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The effect of quartz, administered by intratracheal instillation, on the rat lung. I. The cellular response.经气管内滴注给予石英对大鼠肺的影响。I. 细胞反应。
Environ Res. 1980 Jun;22(1):1-12. doi: 10.1016/0013-9351(80)90113-9.
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Injury versus inflammatory response in the lungs of rats intratracheally inoculated with bacterial lipopolysaccharide.气管内接种细菌脂多糖的大鼠肺部损伤与炎症反应
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