De Panfilis G, Rowden G, Manara G C, Ferrari C, Torresani C, Sansoni P
Department of Dermatology, University of Parma, Italy.
Cell Immunol. 1988 Jul;114(2):398-404. doi: 10.1016/0008-8749(88)90331-0.
The S-100-positive T lymphocytes, and, particularly, the S-100 beta subunit, are restricted, as demonstrated by quantitative subset analysis and double-labeling (gold-peroxidase) immunoelectron microscopy of T-cell subpopulations, to an unique T8-positive cell subset which interestingly was 9.3-negative and CD11b-positive. Since both the T8-positive, 9.3-negative and the T8-positive, CD11b-positive subpopulations have been demonstrated to show suppressive activities, the S-100-positive T cells seem to be closely restricted to a small T-suppressor-cell compartment. Although functional studies on viable isolated S-100 beta-positive cells are impossible to achieve, due to the lack of this protein on the cell membrane, its presence in a discrete T-suppressor compartment might suggest a possible role for the S-100 beta-positive T cells in the regulation of the immune system.
通过对T细胞亚群进行定量亚群分析和双标记（金过氧化物酶）免疫电子显微镜观察发现，S-100阳性T淋巴细胞，尤其是S-100β亚基，局限于一个独特的T8阳性细胞亚群，有趣的是，该亚群9.3阴性且CD11b阳性。由于已证明T8阳性、9.3阴性亚群和T8阳性、CD11b阳性亚群均具有抑制活性，因此S-100阳性T细胞似乎紧密局限于一个小的T抑制细胞区室。尽管由于细胞膜上缺乏这种蛋白质，无法对存活的分离出的S-100β阳性细胞进行功能研究，但它在离散的T抑制区室中的存在可能表明S-100β阳性T细胞在免疫系统调节中可能发挥作用。
