替诺福韦-恩曲他滨-依非韦伦起始时的胎龄对博茨瓦纳不良出生结局的影响。
Effect of Gestational Age at Tenofovir-Emtricitabine-Efavirenz Initiation on Adverse Birth Outcomes in Botswana.
机构信息
Beth Israel Deaconess Medical Center, Division of Infectious Disease, Boston, Massachusetts.
Division of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts.
出版信息
J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e148-e151. doi: 10.1093/jpids/piy006.
Abstract
Among human immunodeficiency virus-positive women in Botswana on the recommended first-line antiretroviral therapy regimen, tenofovir-emtricitabine-efavirenz, initiated within the first or early second trimester, we found no increased risk of stillbirth, neonatal death, preterm/very preterm delivery, or the infant being born small or very small for gestational age. Treatment with tenofovir-emtricitabine-efavirenz <1 year before conception increased the risk of preterm delivery slightly over late-second-trimester treatment initiation (adjusted risk ratio, 1.33 [95% confidence interval, 1.04-1.70]).
摘要
在博茨瓦纳接受推荐的一线抗逆转录病毒治疗方案（替诺福韦-恩曲他滨-依非韦伦）的人类免疫缺陷病毒阳性妇女中，我们发现，在妊娠早期或早期第二孕期开始治疗，并不会增加死胎、新生儿死亡、早产/极早产或婴儿出生时体重过小或小于胎龄的风险。与妊娠晚期开始替诺福韦-恩曲他滨-依非韦伦治疗相比，在妊娠前不到 1 年开始治疗略微增加了早产的风险（校正风险比，1.33 [95%置信区间，1.04-1.70]）。
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